Ngo, T.-E., Ecker, A., Ryu, B., Guild, A., Remmel, A., Boudreau, P. D., Alexander, K. L., Naman, C. B., Glukhov, E., Avalon, N. E., Shende, V. V., Thomas, L., Dahesh, S., Nizet, V., Gerwick, L., & Gerwick, W. H. (2024). Structure and Biosynthesis of Hectoramide B, a Linear Depsipeptide from Marine Cyanobacterium Moorena producens JHB Discovered via Coculture with Candida albicans. ACS Chemical Biology, 19(3), 619–628.
Leão, T. F., Wang, M., da Silva, R., Gurevich, A., Bauermeister, A., Gomes, P. W. P., Brejnrod, A., Glukhov, E., Aron, A. T., Louwen, J. J. R., Kim, H. W., Reher, R., Fiore, M. F., van der Hooft, J. J. J., Gerwick, L., Gerwick, W. H., Bandeira, N., & Dorrestein, P. C. (2022). NPOmix: A machine learning classifier to connect mass spectrometry fragmentation data to biosynthetic gene clusters. PNAS Nexus, 1(5), pgac257.
Taton, A., Rohrer, S., Diaz, B., Reher, R., Caraballo Rodriguez, A. M., Pierce, M. L., Dorrestein, P. C., Gerwick, L., Gerwick, W. H., & Golden, J. W. (2022). Heterologous Expression in Anabaena of the Columbamide Pathway from the Cyanobacterium Moorena bouillonii and Production of New Analogs. ACS Chemical Biology, 17(7), 1910–1923.
Demirkiran, O., Almaliti, J., Leao, T., Navarro, G., Byrum, T., Valeriote, F. A., Gerwick, L., & Gerwick, W. H. (2021). Portobelamides A and B and Caciqueamide, Cytotoxic Peptidic Natural Products from a Caldora sp. Marine Cyanobacterium. Journal of Natural Products, 84(8), 2081–2093.
Schorn, M. A., Verhoeven, S., Ridder, L., Huber, F., Acharya, D. D., Aksenov, A. A., Aleti, G., Moghaddam, J. A., Aron, A. T., Aziz, S., Bauermeister, A., Bauman, K. D., Baunach, M., Beemelmanns, C., Beman, J. M., Berlanga-Clavero, M. V., Blacutt, A. A., Bode, H. B., Boullie, A., … van der Hooft, J. J. J. (2021). A community resource for paired genomic and metabolomic data mining. Nature Chemical Biology.
Christy, M. P., Uekusa, Y., Gerwick, L., & Gerwick, W. H. (2021). Natural products with potential to treat RNA virus pathogens including SARS-CoV-2. Journal of Natural Products, 84(1), 161–182.
Leao, T., Wang, M. X., Moss, N., da Silva, R., Sanders, J., Nurk, S., Gurevich, A., Humphrey, G., Reher, R., Zhu, Q. Y., Belda-Ferre, P., Glukhov, E., Whitner, S., Alexander, K. L., Rex, R., Pevzner, P., Dorrestein, P. C., Knight, R., Bandeira, N., … Gerwick, L. (2021). A multi-omics characterization of the natural product potential of tropical filamentous marine cyanobacteria. Marine Drugs, 19(1).
Taton, A., Ecker, A., Diaz, B., Moss, N. A., Anderson, B., Reher, R., Leao, T. F., Simkovsky, R., Dorrestein, P. C., Gerwick, L., Gerwick, W. H., & Golden, J. W. (2020). Heterologous expression of cryptomaldamide in a cyanobacterial host. Acs Synthetic Biology, 9(12), 3364–3376.
Yang, J. M., Liu, Y. Y., Yang, W. C., Ma, X. X., Nie, Y. Y., Glukhov, E., Gerwick, L., Gerwick, W. H., Lei, X. L., & Zhang, Y. (2020). An anti-inflammatory isoflavone from soybean inoculated with a marine fungusAspergillus terreusC23-3. Bioscience Biotechnology and Biochemistry, 84(8), 1546–1553.
Li, Y. Y., Yu, H. B., Zhang, Y., Leao, T., Glukhov, E., Pierce, M. L., Zhang, C., Kim, H., Mao, H. H., Fang, F., Cottrell, G. W., Murray, T. F., Gerwick, L., Guan, H. S., & Gerwick, W. H. (2020). Pagoamide A, a cyclic depsipeptide isolated from a cultured marine chlorophyte, Derbesia sp., using MS/MS-based molecular networking. Journal of Natural Products, 83(3), 617–625.
Cao, L., Gurevich, A., Alexander, K. L., Naman, C. B., Leao, T., Glukhov, E., Luzzatto-Knaan, T., Vargas, F., Quinn, R., Bouslimani, A., Nothias, L. F., Singh, N. K., Sanders, J. G., Benitez, R. A. S., Thompson, L. R., Hamid, M. N., Morton, J. T., Mikheenko, A., Shlemov, A., … Mohimani, H. (2019). MetaMiner: A scalable peptidogenomics approach for discovery of ribosomal peptide natural products with blind modifications from microbial communities. Cell Systems, 9(6), 600-+.
Yu, H. B., Glukhov, E., Li, Y. Y., Iwasaki, A., Gerwick, L., Dorrestein, P. C., Jiao, B. H., & Gerwick, W. H. (2019). Cytotoxic microcolin lipopeptides from the marine cyanobacterium Moorea producens. Journal of Natural Products, 82(9), 2608–2619.
Moss, N. A., Seiler, G., Leao, T. F., Castro-Falcon, G., Gerwick, L., Hughes, C. C., & Gerwick, W. H. (2019). Nature’s combinatorial biosynthesis produces vatiamides A-F. Angewandte Chemie-International Edition, 58(27), 9027–9031.
Moss, N. A., Leao, T., Rankin, M. R., McCullough, T. M., Qu, P. P., Korobeynikov, A., Smith, J. L., Gerwick, L., & Gerwick, W. H. (2018). Ketoreductase domain dysfunction expands chemodiversity: Malyngamide biosynthesis in the cyanobacterium Okeania hirsuta. Acs Chemical Biology, 13(12), 3385–3395.
Skiba, M. A., Sikkema, A. P., Moss, N. A., Lowell, A. N., Su, M., Sturgis, R. M., Gerwick, L., Gerwick, W. H., Sherman, D. H., & Smith, J. L. (2018). Biosynthesis of t-Butyl in apratoxin A: functional analysis and architecture of a PKS loading module. Acs Chemical Biology, 13(6), 1640–1650.
Mascuch, S. J., Boudreau, P. D., Carland, T. M., Pierce, N. T., Olson, J., Hensler, M. E., Choi, H., Campanale, J., Hamdoun, A., Nizet, V., Gerwick, W. H., Gaasterland, T., & Gerwick, L. (2018). Marine natural product honaucin A attenuates inflammation by activating the Nrf2-ARE pathway. Journal of Natural Products, 81(3), 506–514.
Shao, C. L., Mou, X. F., Cao, F., Spadafora, C., Glukhov, E., Gerwick, L., Wang, C. Y., & Gerwick, W. H. (2018). Bastimolide B, an antimalarial 24-membered marine macrolide possessing a tert-butyl group. Journal of Natural Products, 81(1), 211–215.
Moss, N. A., Leao, T., Glukhov, E., Gerwick, L., & Gerwick, W. H. (2018). Collection, Culturing, and Genome Analyses of Tropical Marine Filamentous Benthic Cyanobacteria. In B. S. Moore (Ed.), Marine Enzymes and Specialized Metabolism, Pt A (Vol. 604, pp. 3–43). Elsevier Academic Press Inc.
Skiba, M. A., Sikkema, A. P., Moss, N. A., Tran, C. L., Sturgis, R. M., Gerwick, L., Gerwick, W. H., Sherman, D. H., & Smith, J. L. (2017). A mononuclear iron-dependent methyltransferase catalyzes initial steps in assembly of the apratoxin A polyketide starter unit. Acs Chemical Biology, 12(12), 3039–3048.
Luzzatto-Knaan, T., Garg, N., Wang, M. X., Glukhov, E., Peng, Y., Ackermann, G., Amir, A., Duggan, B. M., Ryazanov, S., Gerwick, L., Knight, R., Alexandov, T., Bandeira, N., Gerwick, W. H., & Dorrestein, P. C. (2017). Digitizing mass spectrometry data to explore the chemical diversity and distribution of marine cyanobacteria and algae. Elife, 6.
Kinnel, R. B., Esquenazi, E., Leao, T., Moss, N., Mevers, E., Pereira, A. R., Monroe, E. A., Korobeynikov, A., Murray, T. F., Sherman, D., Gerwick, L., Dorrestein, P. C., & Gerwick, W. H. (2017). A maldiisotopic approach to discover natural products: Cryptomaldamide, a hybrid tripeptide from the marine cyanobacterium Moorea producens. Journal of Natural Products, 80(5), 1514–1521.
Leao, T., Castelao, G., Korobeynikov, A., Monroe, E. A., Podell, S., Glukhov, E., Allen, E. E., Gerwick, W. H., & Gerwick, L. (2017). Comparative genomics uncovers the prolific and distinctive metabolic potential of the cyanobacterial genus Moorea. Proceedings of the National Academy of Sciences of the United States of America, 114(12), 3198–3203.
Maloney, F. P., Gerwick, L., Gerwick, W. H., Sherman, D. H., & Smith, J. L. (2016). Anatomy of the beta-branching enzyme of polyketide biosynthesis and its interaction with an acyl-ACP substrate. Proceedings of the National Academy of Sciences of the United States of America, 113(37), 10316–10321.
Wang, M. X., Carver, J. J., Phelan, V. V., Sanchez, L. M., Garg, N., Peng, Y., Nguyen, D. D., Watrous, J., Kapono, C. A., Luzzatto-Knaan, T., Porto, C., Bouslimani, A., Melnik, A. V., Meehan, M. J., Liu, W. T., Criisemann, M., Boudreau, P. D., Esquenazi, E., Sandoval-Calderon, M., … Bandeira, N. (2016). Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking. Nature Biotechnology, 34(8), 828–837.
Cummings, S. L., Barbe, D., Leao, T. F., Korobeynikov, A., Engene, N., Glukhov, E., Gerwick, W. H., & Gerwick, L. (2016). A novel uncultured heterotrophic bacterial associate of the cyanobacterium Moorea producens JHB. Bmc Microbiology, 16.
Moss, N. A., Bertin, M. J., Kleigrewe, K., Leao, T. F., Gerwick, L., & Gerwick, W. H. (2016). Integrating mass spectrometry and genomics for cyanobacterial metabolite discovery. Journal of Industrial Microbiology & Biotechnology, 43(2–3), 313–324.
Bertin, M. J., Vulpanovici, A., Monroe, E. A., Korobeynikov, A., Sherman, D. H., Gerwick, L., & Gerwick, W. H. (2016). The phormidolide biosynthetic gene cluster: A trans-at pks pathway encoding a toxic macrocyclic polyketide. Chembiochem, 17(2), 164–173.
Teta, R., Della Sala, G., Glukhov, E., Gerwick, L., Gerwick, W. H., Mangoni, A., & Costantino, V. (2015). Combined LC-MS/MS and molecular networking approach reveals new cyanotoxins from the 2014 cyanobacterial bloom in Green Lake, Seattle. Environmental Science & Technology, 49(24), 14301–14310.
Shao, C. L., Linington, R. G., Balunas, M. J., Centeno, A., Boudreau, P., Zhang, C., Engene, N., Spadafora, C., Mutka, T. S., Kyle, D. E., Gerwick, L., Wang, C. Y., & Gerwick, W. H. (2015). Bastimolide A, a potent antimalarial polyhydroxy macrolide from the marine cyanobacterium Okeania hirsuta. Journal of Organic Chemistry, 80(16), 7849–7855.
Gerwick, L., Mascuch, S. J., Navarro, G., Boudreau, P., Carland, T. M., Gaasterland, T., & Gerwick, W. H. (2015). Honaucin A, mechanism of action and role as a potential cancer prevention agent. Planta Medica, 81(11), 927–927.
Navarro, G., Cummings, S., Lee, J., Moss, N., Glukhov, E., Valeriote, F. A., Gerwick, L., & Gerwick, W. H. (2015). Isolation of polycavernoside D from a marine cyanobacterium. Environmental Science & Technology Letters, 2(7), 166–170.
Boudreau, P. D., Monroe, E. A., Mehrotra, S., Desfor, S., Korobeynikov, A., Sherman, D. H., Murray, T. F., Gerwick, L., Dorrestein, P. C., & Gerwick, W. H. (2015). Expanding the described metabolome of the marine cyanobacterium Moorea producens JHB through orthogonal natural products workflows. PLOS ONE, 10(7).
Kleigrewe, K., Almaliti, J., Tian, I. Y., Kinnel, R. B., Korobeynikov, A., Monroe, E. A., Duggan, B. M., Di Marzo, V., Sherman, D. H., Dorrestein, P. C., Gerwick, L., & Gerwick, W. H. (2015). Combining mass spectrometric metabolic profiling with genomic analysis: A powerful approach for discovering natural products from cyanobacteria. Journal of Natural Products, 78(7), 1671–1682.
Bertin, M. J., Schwartz, S. L., Lee, J., Korobeynikov, A., Dorrestein, P. C., Gerwick, L., & Gerwick, W. H. (2015). Spongosine production by a Vibrio harveyi strain sssociated with the sponge Tectitethya crypta. Journal of Natural Products, 78(3), 493–499.
Mascuch, S. J., Moree, W. J., Hsu, C. C., Turner, G. G., Cheng, T. L., Blehert, D. S., Kilpatrick, A. M., Frick, W. F., Meehan, M. J., Dorrestein, P. C., & Gerwick, L. (2015). Direct detection of fungal siderophores on bats with white-nose syndrome via fluorescence microscopy-guided ambient ionization mass spectrometry. PLOS ONE, 10(3).
Micallef, M. L., Sharma, D., Bunn, B. M., Gerwick, L., Viswanathan, R., & Moffitt, M. C. (2014). Comparative analysis of hapalindole, ambiguine and welwitindolinone gene clusters and reconstitution of indole-isonitrile biosynthesis from cyanobacteria. Bmc Microbiology, 14.
Coates, R. C., Podell, S., Korobeynikov, A., Lapidus, A., Pevzner, P., Sherman, D. H., Allen, E. E., Gerwick, L., & Gerwick, W. H. (2014). Characterization of cyanobacterial hydrocarbon composition and distribution of biosynthetic pathways. PLOS ONE, 9(1), e85140.
Della Sala, G., Hochmuth, T., Costantino, V., Teta, R., Gerwick, W., Gerwick, L., Piel, J., & Mangoni, A. (2013). Polyketide genes in the marine sponge Plakortis simplex: a new group of mono-modular type I polyketide synthases from sponge symbionts. Environmental Microbiology Reports, 5(6), 809–818.
Gerwick, L., Boudreau, P., Choi, H., Mascuch, S., Villa, F. A., Balunas, M. J., Malloy, K. L., Teasdale, M. E., Rowley, D. C., & Gerwick, W. H. (2013). Interkingdom signaling by structurally related cyanobacterial and algal secondary metabolites. Phytochemistry Reviews, 12(3), 459–465.
Hsu, C. C., ElNaggar, M. S., Peng, Y., Fang, J. S., Sanchez, L. M., Mascuch, S. J., Moller, K. A., Alazzeh, E. K., Pikula, J., Quinn, R. A., Zeng, Y., Wolfe, B. E., Dutton, R. J., Gerwick, L., Zhang, L. X., Liu, X. T., Mansson, M., & Dorrestein, P. C. (2013). Real-time metabolomics on living microorganisms using ambient electrospray ionization flow-probe. Analytical Chemistry, 85(15), 7014–7018.
Sanchez, L. M., Knudsen, G. M., Helbig, C., De Muylder, G., Mascuch, S. M., Mackey, Z. B., Gerwick, L., Clayton, C., McKerrow, J. H., & Linington, R. G. (2013). Examination of the Mode of Action of the Almiramide Family of Natural Products against the Kinetoplastid Parasite Trypanosoma brucei. Journal of Natural Products, 76(4), 630–641.
McCarthy, J. G., Eisman, E. B., Kulkarni, S., Gerwick, L., Gerwick, W. H., Wipf, P., Sherman, D. H., & Smith, J. L. (2012). Structural basis of functional group activation by sulfotransferases in complex metabolic pathways. Acs Chemical Biology, 7(12), 1994–2003.
Balunas, M. J., Grosso, M. F., Villa, F. A., Engene, N., McPhail, K. L., Tidgewell, K., Pineda, L. M., Gerwick, L., Spadafora, C., Kyle, D. E., & Gerwick, W. H. (2012). Coibacins A-D, antileishmanial marine cyanobacterial polyketides with intriguing biosynthetic origins. Organic Letters, 14(15), 3878–3881.
Kim, J. W., Gerwick, L., & Park, C. I. (2012). Molecular identification and expression analysis of two distinct BPI/LBPs (bactericidal permeability-increasing protein/LPS-binding protein) from rock bream, Oplegnathus fasciatus. Fish & Shellfish Immunology, 33(1), 75–84.
Choi, H., Mascuch, S. J., Villa, F. A., Byrum, T., Teasdale, M. E., Smith, J. E., Preskitt, L. B., Rowley, D. C., Gerwick, L., & Gerwick, W. H. (2012). Honaucins A-C, potent inhibitors of inflammation and bacterial quorum sensing: synthetic derivatives and structure-activity relationships. Chemistry & Biology, 19(5), 589–598.
Jones, A. C., Ottilie, S., Eustaquio, A. S., Edwards, D. J., Gerwick, L., Moore, B. S., & Gerwick, W. H. (2012). Evaluation of Streptomyces coelicolor A3(2) as a heterologous expression host for the cyanobacterial protein kinase C activator lyngbyatoxin A. FEBS Journal, 279(7), 1243–1251.
Gehret, J. J., Gu, L. C., Geders, T. W., Brown, W. C., Gerwick, L., Gerwick, W. H., Sherman, D. H., & Smith, J. L. (2012). Structure and activity of DmmA, a marine haloalkane dehalogenase. Protein Science, 21(2), 239–248.
Carland, T. M., Locke, J. B., Nizet, V., & Gerwick, L. (2012). Differential expression and intrachromosomal evolution of the sghC1q genes in zebrafish (Danio rerio). Developmental and Comparative Immunology, 36(1), 31–38.
Engene, N., Choi, H., Esquenazi, E., Byrum, T., Villa, F. A., Cao, Z. Y., Murray, T. F., Dorrestein, P. C., Gerwick, L., & Gerwick, W. H. (2011). Phylogeny-guided isolation of ethyl tumonoate a from the marine cyanobacterium cf. Oscillatoria margaritifera. Journal of Natural Products, 74(8), 1737–1743.
Udwary, D. W., Gontang, E. A., Jones, A. C., Jones, C. S., Schultz, A. W., Winter, J. M., Yang, J. Y., Beauchemin, N., Capson, T. L., Clark, B. R., Esquenazi, E., Eustaquio, A. S., Freel, K., Gerwick, L., Gerwick, W. H., Gonzalez, D., Liu, W. T., Malloy, K. L., Maloney, K. N., … Moore, B. S. (2011). Significant natural product biosynthetic potential of actinorhizal symbionts of the genus Frankia, as revealed by comparative genomic and proteomic analyses. Applied and Environmental Microbiology, 77(11), 3617–3625.