Publications

69 publications

2021

Schorn, M. A., Verhoeven, S., Ridder, L., Huber, F., Acharya, D. D., Aksenov, A. A., ... van der Hooft, J. J. J. (2021). A community resource for paired genomic and metabolomic data mining. Nature Chemical Biology. doi: 10.1038/s41589-020-00724-z
Leao, T., Wang, M. X., Moss, N., da Silva, R., Sanders, J., Nurk, S., ... Gerwick, L. (2021). A multi-omics characterization of the natural product potential of tropical filamentous marine cyanobacteria. Marine Drugs, 19(1). doi: 10.3390/md19010020
Christy, M. P., Uekusa, Y., Gerwick, L., & Gerwick, W. H. (2021). Natural products with potential to treat RNA virus pathogens including SARS-CoV-2. Journal of Natural Products, 84(1), 161-182. doi: 10.1021/acs.jnatprod.0c00968

2020

Taton, A., Ecker, A., Diaz, B., Moss, N. A., Anderson, B., Reher, R., ... Golden, J. W. (2020). Heterologous expression of cryptomaldamide in a cyanobacterial host. Acs Synthetic Biology, 9(12), 3364-3376. doi: 10.1021/acssynbio.0c00431
Yang, J. M., Liu, Y. Y., Yang, W. C., Ma, X. X., Nie, Y. Y., Glukhov, E., ... Zhang, Y. (2020). An anti-inflammatory isoflavone from soybean inoculated with a marine fungusAspergillus terreusC23-3. Bioscience Biotechnology and Biochemistry, 84(8), 1546-1553. doi: 10.1080/09168451.2020.1764838
Li, Y. Y., Yu, H. B., Zhang, Y., Leao, T., Glukhov, E., Pierce, M. L., ... Gerwick, W. H. (2020). Pagoamide A, a cyclic depsipeptide isolated from a cultured marine chlorophyte, Derbesia sp., using MS/MS-based molecular networking. Journal of Natural Products, 83(3), 617-625. doi: 10.1021/acs.jnatprod.9b01019

2019

Cao, L., Gurevich, A., Alexander, K. L., Naman, C. B., Leao, T., Glukhov, E., ... Mohimani, H. (2019). MetaMiner: A scalable peptidogenomics approach for discovery of ribosomal peptide natural products with blind modifications from microbial communities. Cell Systems, 9(6), 600-+. doi: 10.1016/j.cels.2019.09.004
Yu, H. B., Glukhov, E., Li, Y. Y., Iwasaki, A., Gerwick, L., Dorrestein, P. C., ... Gerwick, W. H. (2019). Cytotoxic microcolin lipopeptides from the marine cyanobacterium Moorea producens. Journal of Natural Products, 82(9), 2608-2619. doi: 10.1021/acs.jnatprod.9b00549
Moss, N. A., Seiler, G., Leao, T. F., Castro-Falcon, G., Gerwick, L., Hughes, C. C., & Gerwick, W. H. (2019). Nature's combinatorial biosynthesis produces vatiamides A-F. Angewandte Chemie-International Edition, 58(27), 9027-9031. doi: 10.1002/anie.201902571

2018

Moss, N. A., Leao, T., Rankin, M. R., McCullough, T. M., Qu, P. P., Korobeynikov, A., ... Gerwick, W. H. (2018). Ketoreductase domain dysfunction expands chemodiversity: Malyngamide biosynthesis in the cyanobacterium Okeania hirsuta. Acs Chemical Biology, 13(12), 3385-3395. doi: 10.1021/acschembio.8b00910
Skiba, M. A., Sikkema, A. P., Moss, N. A., Lowell, A. N., Su, M., Sturgis, R. M., ... Smith, J. L. (2018). Biosynthesis of t-Butyl in apratoxin A: functional analysis and architecture of a PKS loading module. Acs Chemical Biology, 13(6), 1640-1650. doi: 10.1021/acschembio.8b00252
Mascuch, S. J., Boudreau, P. D., Carland, T. M., Pierce, N. T., Olson, J., Hensler, M. E., ... Gerwick, L. (2018). Marine natural product honaucin A attenuates inflammation by activating the Nrf2-ARE pathway. Journal of Natural Products, 81(3), 506-514. doi: 10.1021/acs.jnatprod.7b00734
Shao, C. L., Mou, X. F., Cao, F., Spadafora, C., Glukhov, E., Gerwick, L., ... Gerwick, W. H. (2018). Bastimolide B, an antimalarial 24-membered marine macrolide possessing a tert-butyl group. Journal of Natural Products, 81(1), 211-215. doi: 10.1021/acs.jnatprod.7b00917
Moss, N. A., Leao, T., Glukhov, E., Gerwick, L., & Gerwick, W. H. (2018). Collection, Culturing, and Genome Analyses of Tropical Marine Filamentous Benthic Cyanobacteria. Marine Enzymes and Specialized Metabolism, Pt A (pp. 3-43). San Diego: Elsevier Academic Press Inc. doi: 10.1016/bs.mie.2018.02.014

2017

Skiba, M. A., Sikkema, A. P., Moss, N. A., Tran, C. L., Sturgis, R. M., Gerwick, L., ... Smith, J. L. (2017). A mononuclear iron-dependent methyltransferase catalyzes initial steps in assembly of the apratoxin A polyketide starter unit. Acs Chemical Biology, 12(12), 3039-3048. doi: 10.1021/acschembio.7b00746
Kinnel, R. B., Esquenazi, E., Leao, T., Moss, N., Mevers, E., Pereira, A. R., ... Gerwick, W. H. (2017). A maldiisotopic approach to discover natural products: Cryptomaldamide, a hybrid tripeptide from the marine cyanobacterium Moorea producens. Journal of Natural Products, 80(5), 1514-1521. doi: 10.1021/acs.jnatprod.7b00019
Luzzatto-Knaan, T., Garg, N., Wang, M. X., Glukhov, E., Peng, Y., Ackermann, G., ... Dorrestein, P. C. (2017). Digitizing mass spectrometry data to explore the chemical diversity and distribution of marine cyanobacteria and algae. Elife, 6(e24214). doi: 10.7554/eLife.24214
Leao, T., Castelao, G., Korobeynikov, A., Monroe, E. A., Podell, S., Glukhov, E., ... Gerwick, L. (2017). Comparative genomics uncovers the prolific and distinctive metabolic potential of the cyanobacterial genus Moorea. Proceedings of the National Academy of Sciences of the United States of America, 114(12), 3198-3203. doi: 10.1073/pnas.1618556114

2016

Maloney, F. P., Gerwick, L., Gerwick, W. H., Sherman, D. H., & Smith, J. L. (2016). Anatomy of the beta-branching enzyme of polyketide biosynthesis and its interaction with an acyl-ACP substrate. Proceedings of the National Academy of Sciences of the United States of America, 113(37), 10316-10321. doi: 10.1073/pnas.1607210113
Cummings, S. L., Barbe, D., Leao, T. F., Korobeynikov, A., Engene, N., Glukhov, E., ... Gerwick, L. (2016). A novel uncultured heterotrophic bacterial associate of the cyanobacterium Moorea producens JHB. Bmc Microbiology, 16(198). doi: 10.1186/s12866-016-0817-1
Wang, M. X., Carver, J. J., Phelan, V. V., Sanchez, L. M., Garg, N., Peng, Y., ... Bandeira, N. (2016). Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking. Nature Biotechnology, 34(8), 828-837. doi: 10.1038/nbt.3597
Moss, N. A., Bertin, M. J., Kleigrewe, K., Leao, T. F., Gerwick, L., & Gerwick, W. H. (2016). Integrating mass spectrometry and genomics for cyanobacterial metabolite discovery. Journal of Industrial Microbiology & Biotechnology, 43(2-3), 313-324. doi: 10.1007/s10295-015-1705-7
Bertin, M. J., Vulpanovici, A., Monroe, E. A., Korobeynikov, A., Sherman, D. H., Gerwick, L., & Gerwick, W. H. (2016). The phormidolide biosynthetic gene cluster: A trans-at pks pathway encoding a toxic macrocyclic polyketide. Chembiochem, 17(2), 164-173. doi: 10.1002/cbic.201500467

2015

Teta, R., Della Sala, G., Glukhov, E., Gerwick, L., Gerwick, W. H., Mangoni, A., & Costantino, V. (2015). Combined LC-MS/MS and molecular networking approach reveals new cyanotoxins from the 2014 cyanobacterial bloom in Green Lake, Seattle. Environmental Science & Technology, 49(24), 14301-14310. doi: 10.1021/acs.est.5b04415
Shao, C. L., Linington, R. G., Balunas, M. J., Centeno, A., Boudreau, P., Zhang, C., ... Gerwick, W. H. (2015). Bastimolide A, a potent antimalarial polyhydroxy macrolide from the marine cyanobacterium Okeania hirsuta. Journal of Organic Chemistry, 80(16), 7849-7855. doi: 10.1021/acs.joc.5b01264
Boudreau, P. D., Monroe, E. A., Mehrotra, S., Desfor, S., Korobeynikov, A., Sherman, D. H., ... Gerwick, W. H. (2015). Expanding the described metabolome of the marine cyanobacterium Moorea producens JHB through orthogonal natural products workflows. Plos One, 10(7). doi: 10.1371/journal.pone.0133297
Navarro, G., Cummings, S., Lee, J., Moss, N., Glukhov, E., Valeriote, F. A., ... Gerwick, W. H. (2015). Isolation of polycavernoside D from a marine cyanobacterium. Environmental Science & Technology Letters, 2(7), 166-170. doi: 10.1021/acs.estlett.5b00116
Kleigrewe, K., Almaliti, J., Tian, I. Y., Kinnel, R. B., Korobeynikov, A., Monroe, E. A., ... Gerwick, W. H. (2015). Combining mass spectrometric metabolic profiling with genomic analysis: A powerful approach for discovering natural products from cyanobacteria. Journal of Natural Products, 78(7), 1671-1682. doi: 10.1021/acs.jnatprod.5b00301
Gerwick, L., Mascuch, S. J., Navarro, G., Boudreau, P., Carland, T. M., Gaasterland, T., & Gerwick, W. H. (2015). Honaucin A, mechanism of action and role as a potential cancer prevention agent. Planta Medica, 81(11), 927-927.
Mascuch, S. J., Moree, W. J., Hsu, C. C., Turner, G. G., Cheng, T. L., Blehert, D. S., ... Gerwick, L. (2015). Direct detection of fungal siderophores on bats with white-nose syndrome via fluorescence microscopy-guided ambient ionization mass spectrometry. Plos One, 10(3). doi: 10.1371/journal.pone.0119668
Bertin, M. J., Schwartz, S. L., Lee, J., Korobeynikov, A., Dorrestein, P. C., Gerwick, L., & Gerwick, W. H. (2015). Spongosine production by a Vibrio harveyi strain sssociated with the sponge Tectitethya crypta. Journal of Natural Products, 78(3), 493-499. doi: 10.1021/np5009762

2014

Micallef, M. L., Sharma, D., Bunn, B. M., Gerwick, L., Viswanathan, R., & Moffitt, M. C. (2014). Comparative analysis of hapalindole, ambiguine and welwitindolinone gene clusters and reconstitution of indole-isonitrile biosynthesis from cyanobacteria. Bmc Microbiology, 14(213). doi: 10.1186/s12866-014-0213-7
Coates, R. C., Podell, S., Korobeynikov, A., Lapidus, A., Pevzner, P., Sherman, D. H., ... Gerwick, W. H. (2014). Characterization of cyanobacterial hydrocarbon composition and distribution of biosynthetic pathways. PLoS ONE, 9(1), e85140. doi: 10.1371/journal.pone.0085140

2013

Della Sala, G., Hochmuth, T., Costantino, V., Teta, R., Gerwick, W., Gerwick, L., ... Mangoni, A. (2013). Polyketide genes in the marine sponge Plakortis simplex: a new group of mono-modular type I polyketide synthases from sponge symbionts. Environmental Microbiology Reports, 5(6), 809-818. doi: 10.1111/1758-2229.12081
Gerwick, L., Boudreau, P., Choi, H., Mascuch, S., Villa, F. A., Balunas, M. J., ... Gerwick, W. H. (2013). Interkingdom signaling by structurally related cyanobacterial and algal secondary metabolites. Phytochemistry Reviews, 12(3), 459-465. doi: 10.1007/s11101-012-9237-5
Hsu, C. C., ElNaggar, M. S., Peng, Y., Fang, J. S., Sanchez, L. M., Mascuch, S. J., ... Dorrestein, P. C. (2013). Real-time metabolomics on living microorganisms using ambient electrospray ionization flow-probe. Analytical Chemistry, 85(15), 7014-7018. doi: 10.1021/ac401613x
Sanchez, L. M., Knudsen, G. M., Helbig, C., De Muylder, G., Mascuch, S. M., Mackey, Z. B., ... Linington, R. G. (2013). Examination of the Mode of Action of the Almiramide Family of Natural Products against the Kinetoplastid Parasite Trypanosoma brucei. Journal of Natural Products, 76(4), 630-641. doi: 10.1021/np300834q

2012

McCarthy, J. G., Eisman, E. B., Kulkarni, S., Gerwick, L., Gerwick, W. H., Wipf, P., ... Smith, J. L. (2012). Structural basis of functional group activation by sulfotransferases in complex metabolic pathways. ACS Chemical Biology, 7(12), 1994-2003. doi: 10.1021/cb300385m
Balunas, M. J., Grosso, M. F., Villa, F. A., Engene, N., McPhail, K. L., Tidgewell, K., ... Gerwick, W. H. (2012). Coibacins A-D, antileishmanial marine cyanobacterial polyketides with intriguing biosynthetic origins. Organic Letters, 14(15), 3878-3881. doi: 10.1021/ol301607q
Kim, J. W., Gerwick, L., & Park, C. I. (2012). Molecular identification and expression analysis of two distinct BPI/LBPs (bactericidal permeability-increasing protein/LPS-binding protein) from rock bream, Oplegnathus fasciatus. Fish & Shellfish Immunology, 33(1), 75-84. doi: 10.1016/j.fsi.2012.04.003
Choi, H., Mascuch, S. J., Villa, F. A., Byrum, T., Teasdale, M. E., Smith, J. E., ... Gerwick, W. H. (2012). Honaucins A-C, potent inhibitors of inflammation and bacterial quorum sensing: synthetic derivatives and structure-activity relationships. Chemistry & Biology, 19(5), 589-598. doi: 10.1016/j.chembiol.2012.03.014
Jones, A. C., Ottilie, S., Eustaquio, A. S., Edwards, D. J., Gerwick, L., Moore, B. S., & Gerwick, W. H. (2012). Evaluation of Streptomyces coelicolor A3(2) as a heterologous expression host for the cyanobacterial protein kinase C activator lyngbyatoxin A. FEBS Journal, 279(7), 1243-1251. doi: 10.1111/j.1742-4658.2012.08517.x
Gehret, J. J., Gu, L. C., Geders, T. W., Brown, W. C., Gerwick, L., Gerwick, W. H., ... Smith, J. L. (2012). Structure and activity of DmmA, a marine haloalkane dehalogenase. Protein Science, 21(2), 239-248. doi: 10.1002/pro.2009
Carland, T. M., Locke, J. B., Nizet, V., & Gerwick, L. (2012). Differential expression and intrachromosomal evolution of the sghC1q genes in zebrafish (Danio rerio). Developmental and Comparative Immunology, 36(1), 31-38. doi: 10.1016/j.dci.2011.05.013

2011

Engene, N., Choi, H., Esquenazi, E., Byrum, T., Villa, F. A., Cao, Z. Y., ... Gerwick, W. H. (2011). Phylogeny-guided isolation of ethyl tumonoate a from the marine cyanobacterium cf. Oscillatoria margaritifera. Journal of Natural Products, 74(8), 1737-1743. doi: 10.1021/np200236c
Udwary, D. W., Gontang, E. A., Jones, A. C., Jones, C. S., Schultz, A. W., Winter, J. M., ... Moore, B. S. (2011). Significant natural product biosynthetic potential of actinorhizal symbionts of the genus Frankia, as revealed by comparative genomic and proteomic analyses. Applied and Environmental Microbiology, 77(11), 3617-3625. doi: 10.1128/aem.00038-11
Jones, A. C., Monroe, E. A., Podell, S., Hess, W. R., Klages, S., Esquenazi, E., ... Gerwick, L. (2011). Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula. Proceedings of the National Academy of Sciences of the United States of America, 108(21), 8815-8820. doi: 10.1073/pnas.1101137108
Grindberg, R. V., Ishoey, T., Brinza, D., Esquenazi, E., Coates, R. C., Liu, W. T., ... Gerwick, W. H. (2011). Single cell genome amplification accelerates identification of the apratoxin biosynthetic pathway from a complex microbial assemblage. PLoS One, 6(4). doi: 10.1371/journal.pone.0018565
Malloy, K. L., Villa, F. A., Engene, N., Matainaho, T., Gerwick, L., & Gerwick, W. H. (2011). Malyngamide 2, an oxidized lipopeptide with nitric oxide inhibiting activity from a Papua New Guinea marine cyanobacterium. Journal of Natural Products, 74(1), 95-98. doi: 10.1021/np1005407

2010

Carland, T. M., & Gerwick, L. (2010). The C1q domain containing proteins: Where do they come from and what do they do?. Developmental and Comparative Immunology, 34(8), 785-790. doi: 10.1016/j.dci.2010.02.014
Villa, F. A., & Gerwick, L. (2010). Marine natural product drug discovery: Leads for treatment of inflammation, cancer, infections, and neurological disorders. Immunopharmacology and Immunotoxicology, 32(2), 228-237. doi: 10.3109/08923970903296136
Villa, F. A., Lieske, K., & Gerwick, L. (2010). Selective MyD88-dependent pathway inhibition by the cyanobacterial natural product malyngamide F acetate. European Journal of Pharmacology, 629(1-3), 140-146. doi: 10.1016/j.ejphar.2009.12.002
Jones, A. C., Monroe, E. A., Eisman, E. B., Gerwick, L., Sherman, D. H., & Gerwick, W. H. (2010). The unique mechanistic transformations involved in the biosynthesis of modular natural products from marine cyanobacteria. Natural Product Reports, 27(7), 1048-1065. doi: 10.1039/c000535e

2009

Jones, A. C., Gerwick, L., Gonzalez, D., Dorrestein, P. C., & Gerwick, W. H. (2009). Transcriptional analysis of the jamaicamide gene cluster from the marine cyanobacterium Lyngbya majuscula and identification of possible regulatory proteins. BMC Microbiology, 9(247). doi: 10.1186/1471-2180-9-247
Gu, L. C., Wang, B., Kulkarni, A., Gehret, J. J., Lloyd, K. R., Gerwick, L., ... Sherman, D. H. (2009). Polyketide decarboxylative chain termination preceded by o-sulfonation in curacin a biosynthesis. Journal of the American Chemical Society, 131(44), 16033-+. doi: 10.1021/ja9071578
Gu, L. C., Wang, B., Kulkarni, A., Geders, T. W., Grindberg, R. V., Gerwick, L., ... Sherman, D. H. (2009). Metamorphic enzyme assembly in polyketide diversification. Nature, 459(7247), 731-735. doi: 10.1038/nature07870

2008

Simmons, T. L., Engene, N., Urena, L. D., Romero, L. I., Ortega-Barria, E., Gerwick, L., & Gerwick, W. H. (2008). Viridamides A and B, lipodepsipeptides with antiprotozoal activity from the marine cyanobacterium Oscillatoria nigro-viridis. Journal of Natural Products, 71(9), 1544-1550. doi: 10.1021/np800110e
Gerwick, L., Gerwick, W. H., Coates, R. C., Engene, N., Grindberg, R. V., Jones, A. C., & Sorrels, C. M. (2008). Giant marine cyanobacteria produce exciting potential pharmaceuticals. Microbe, 3(6), 277-284.

2007

Momoda, T. S., Schwindt, A. R., Feist, G. W., Gerwick, L., Bayne, C. J., & Schreck, C. B. (2007). Gene expression in the liver of rainbow trout, Oncorhynchus mykiss, during the stress response. Comparative Biochemistry and Physiology D-Genomics & Proteomics, 2(4), 303-315. doi: 10.1016/j.cbd.2007.06.002
Gerwick, L., Corley-Smith, G., & Bayne, C. J. (2007). Gene transcript changes in individual rainbow trout livers following an inflammatory stimulus. Fish & Shellfish Immunology, 22(3), 157-171. doi: 10.1016/j.fsi.2006.04.003

2002

Gerwick, L., Steinhauer, R., Lapatra, S., Sandell, T., Ortuno, J., Hajiseyedjavadi, N., & Bayne, C. J. (2002). The acute phase response of rainbow trout (Oncorhynchus mykiss) plasma proteins to viral, bacterial and fungal inflammatory agents. Fish & Shellfish Immunology, 12(3), 229-242. doi: 10.1006/fsim.2001.0367

2001

Bayne, C. J., & Gerwick, L. (2001). The acute phase response and innate immunity of fish. Developmental and Comparative Immunology, 25(8-9), 725-743. doi: 10.1016/s0145-305x(01)00033-7
Bayne, C. J., Gerwick, L., Fujiki, K., Nakao, M., & Yano, T. (2001). Immune-relevant (including acute phase) genes identified in the livers of rainbow trout, Oncorhynchus mykiss, by means of suppression subtractive hybridization. Developmental and Comparative Immunology, 25(3), 205-217. doi: 10.1016/s0145-305x(00)00057-4

2000

Gerwick, L., Reynolds, W. S., & Bayne, C. J. (2000). A precerebellin-like protein is part of the acute phase response in rainbow trout, Oncorhynchus mykiss. Developmental and Comparative Immunology, 24(6-7), 597-607. doi: 10.1016/s0145-305x(00)00016-1

1999

Gerwick, L., Demers, N. E., & Bayne, C. J. (1999). Modulation of stress hormones in rainbow trout by means of anesthesia, sensory deprivation and receptor blockade. Comparative Biochemistry and Physiology a-Molecular and Integrative Physiology, 124(3), 329-334. doi: 10.1016/s1095-6433(99)00126-9

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