70 publications

2021

• Demirkiran, O., Almaliti, J., Leao, T., Navarro, G., Byrum, T., Valeriote, F. A., ... Gerwick, W. H. (2021). Portobelamides A and B and Caciqueamide, Cytotoxic Peptidic Natural Products from a Caldora sp. Marine Cyanobacterium. Journal of Natural Products, 84(8), 2081-2093. doi: 10.1021/acs.jnatprod.0c01383
• Schorn, M. A., Verhoeven, S., Ridder, L., Huber, F., Acharya, D. D., Aksenov, A. A., ... van der Hooft, J. J. J. (2021). A community resource for paired genomic and metabolomic data mining. Nature Chemical Biology. doi: 10.1038/s41589-020-00724-z
• Leao, T., Wang, M. X., Moss, N., da Silva, R., Sanders, J., Nurk, S., ... Gerwick, L. (2021). A multi-omics characterization of the natural product potential of tropical filamentous marine cyanobacteria. Marine Drugs, 19(1). doi: 10.3390/md19010020
• Christy, M. P., Uekusa, Y., Gerwick, L., & Gerwick, W. H. (2021). Natural products with potential to treat RNA virus pathogens including SARS-CoV-2. Journal of Natural Products, 84(1), 161-182. doi: 10.1021/acs.jnatprod.0c00968

2020

• Taton, A., Ecker, A., Diaz, B., Moss, N. A., Anderson, B., Reher, R., ... Golden, J. W. (2020). Heterologous expression of cryptomaldamide in a cyanobacterial host. Acs Synthetic Biology, 9(12), 3364-3376. doi: 10.1021/acssynbio.0c00431
• Yang, J. M., Liu, Y. Y., Yang, W. C., Ma, X. X., Nie, Y. Y., Glukhov, E., ... Zhang, Y. (2020). An anti-inflammatory isoflavone from soybean inoculated with a marine fungusAspergillus terreusC23-3. Bioscience Biotechnology and Biochemistry, 84(8), 1546-1553. doi: 10.1080/09168451.2020.1764838
• Li, Y. Y., Yu, H. B., Zhang, Y., Leao, T., Glukhov, E., Pierce, M. L., ... Gerwick, W. H. (2020). Pagoamide A, a cyclic depsipeptide isolated from a cultured marine chlorophyte, Derbesia sp., using MS/MS-based molecular networking. Journal of Natural Products, 83(3), 617-625. doi: 10.1021/acs.jnatprod.9b01019

2019

• Cao, L., Gurevich, A., Alexander, K. L., Naman, C. B., Leao, T., Glukhov, E., ... Mohimani, H. (2019). MetaMiner: A scalable peptidogenomics approach for discovery of ribosomal peptide natural products with blind modifications from microbial communities. Cell Systems, 9(6), 600-+. doi: 10.1016/j.cels.2019.09.004
• Yu, H. B., Glukhov, E., Li, Y. Y., Iwasaki, A., Gerwick, L., Dorrestein, P. C., ... Gerwick, W. H. (2019). Cytotoxic microcolin lipopeptides from the marine cyanobacterium Moorea producens. Journal of Natural Products, 82(9), 2608-2619. doi: 10.1021/acs.jnatprod.9b00549
• Moss, N. A., Seiler, G., Leao, T. F., Castro-Falcon, G., Gerwick, L., Hughes, C. C., & Gerwick, W. H. (2019). Nature's combinatorial biosynthesis produces vatiamides A-F. Angewandte Chemie-International Edition, 58(27), 9027-9031. doi: 10.1002/anie.201902571

2018

• Moss, N. A., Leao, T., Rankin, M. R., McCullough, T. M., Qu, P. P., Korobeynikov, A., ... Gerwick, W. H. (2018). Ketoreductase domain dysfunction expands chemodiversity: Malyngamide biosynthesis in the cyanobacterium Okeania hirsuta. Acs Chemical Biology, 13(12), 3385-3395. doi: 10.1021/acschembio.8b00910
• Skiba, M. A., Sikkema, A. P., Moss, N. A., Lowell, A. N., Su, M., Sturgis, R. M., ... Smith, J. L. (2018). Biosynthesis of t-Butyl in apratoxin A: functional analysis and architecture of a PKS loading module. Acs Chemical Biology, 13(6), 1640-1650. doi: 10.1021/acschembio.8b00252
• Mascuch, S. J., Boudreau, P. D., Carland, T. M., Pierce, N. T., Olson, J., Hensler, M. E., ... Gerwick, L. (2018). Marine natural product honaucin A attenuates inflammation by activating the Nrf2-ARE pathway. Journal of Natural Products, 81(3), 506-514. doi: 10.1021/acs.jnatprod.7b00734
• Shao, C. L., Mou, X. F., Cao, F., Spadafora, C., Glukhov, E., Gerwick, L., ... Gerwick, W. H. (2018). Bastimolide B, an antimalarial 24-membered marine macrolide possessing a tert-butyl group. Journal of Natural Products, 81(1), 211-215. doi: 10.1021/acs.jnatprod.7b00917
• Moss, N. A., Leao, T., Glukhov, E., Gerwick, L., & Gerwick, W. H. (2018). Collection, Culturing, and Genome Analyses of Tropical Marine Filamentous Benthic Cyanobacteria. Marine Enzymes and Specialized Metabolism, Pt A (pp. 3-43). San Diego: Elsevier Academic Press Inc. doi: 10.1016/bs.mie.2018.02.014

2017

• Skiba, M. A., Sikkema, A. P., Moss, N. A., Tran, C. L., Sturgis, R. M., Gerwick, L., ... Smith, J. L. (2017). A mononuclear iron-dependent methyltransferase catalyzes initial steps in assembly of the apratoxin A polyketide starter unit. Acs Chemical Biology, 12(12), 3039-3048. doi: 10.1021/acschembio.7b00746
• Luzzatto-Knaan, T., Garg, N., Wang, M. X., Glukhov, E., Peng, Y., Ackermann, G., ... Dorrestein, P. C. (2017). Digitizing mass spectrometry data to explore the chemical diversity and distribution of marine cyanobacteria and algae. Elife, 6(e24214). doi: 10.7554/eLife.24214
• Kinnel, R. B., Esquenazi, E., Leao, T., Moss, N., Mevers, E., Pereira, A. R., ... Gerwick, W. H. (2017). A maldiisotopic approach to discover natural products: Cryptomaldamide, a hybrid tripeptide from the marine cyanobacterium Moorea producens. Journal of Natural Products, 80(5), 1514-1521. doi: 10.1021/acs.jnatprod.7b00019
• Leao, T., Castelao, G., Korobeynikov, A., Monroe, E. A., Podell, S., Glukhov, E., ... Gerwick, L. (2017). Comparative genomics uncovers the prolific and distinctive metabolic potential of the cyanobacterial genus Moorea. Proceedings of the National Academy of Sciences of the United States of America, 114(12), 3198-3203. doi: 10.1073/pnas.1618556114

2016

• Maloney, F. P., Gerwick, L., Gerwick, W. H., Sherman, D. H., & Smith, J. L. (2016). Anatomy of the beta-branching enzyme of polyketide biosynthesis and its interaction with an acyl-ACP substrate. Proceedings of the National Academy of Sciences of the United States of America, 113(37), 10316-10321. doi: 10.1073/pnas.1607210113
• Cummings, S. L., Barbe, D., Leao, T. F., Korobeynikov, A., Engene, N., Glukhov, E., ... Gerwick, L. (2016). A novel uncultured heterotrophic bacterial associate of the cyanobacterium Moorea producens JHB. Bmc Microbiology, 16(198). doi: 10.1186/s12866-016-0817-1
• Wang, M. X., Carver, J. J., Phelan, V. V., Sanchez, L. M., Garg, N., Peng, Y., ... Bandeira, N. (2016). Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking. Nature Biotechnology, 34(8), 828-837. doi: 10.1038/nbt.3597
• Moss, N. A., Bertin, M. J., Kleigrewe, K., Leao, T. F., Gerwick, L., & Gerwick, W. H. (2016). Integrating mass spectrometry and genomics for cyanobacterial metabolite discovery. Journal of Industrial Microbiology & Biotechnology, 43(2-3), 313-324. doi: 10.1007/s10295-015-1705-7
• Bertin, M. J., Vulpanovici, A., Monroe, E. A., Korobeynikov, A., Sherman, D. H., Gerwick, L., & Gerwick, W. H. (2016). The phormidolide biosynthetic gene cluster: A trans-at pks pathway encoding a toxic macrocyclic polyketide. Chembiochem, 17(2), 164-173. doi: 10.1002/cbic.201500467

2015

• Teta, R., Della Sala, G., Glukhov, E., Gerwick, L., Gerwick, W. H., Mangoni, A., & Costantino, V. (2015). Combined LC-MS/MS and molecular networking approach reveals new cyanotoxins from the 2014 cyanobacterial bloom in Green Lake, Seattle. Environmental Science & Technology, 49(24), 14301-14310. doi: 10.1021/acs.est.5b04415
• Shao, C. L., Linington, R. G., Balunas, M. J., Centeno, A., Boudreau, P., Zhang, C., ... Gerwick, W. H. (2015). Bastimolide A, a potent antimalarial polyhydroxy macrolide from the marine cyanobacterium Okeania hirsuta. Journal of Organic Chemistry, 80(16), 7849-7855. doi: 10.1021/acs.joc.5b01264
• Kleigrewe, K., Almaliti, J., Tian, I. Y., Kinnel, R. B., Korobeynikov, A., Monroe, E. A., ... Gerwick, W. H. (2015). Combining mass spectrometric metabolic profiling with genomic analysis: A powerful approach for discovering natural products from cyanobacteria. Journal of Natural Products, 78(7), 1671-1682. doi: 10.1021/acs.jnatprod.5b00301
• Navarro, G., Cummings, S., Lee, J., Moss, N., Glukhov, E., Valeriote, F. A., ... Gerwick, W. H. (2015). Isolation of polycavernoside D from a marine cyanobacterium. Environmental Science & Technology Letters, 2(7), 166-170. doi: 10.1021/acs.estlett.5b00116
• Gerwick, L., Mascuch, S. J., Navarro, G., Boudreau, P., Carland, T. M., Gaasterland, T., & Gerwick, W. H. (2015). Honaucin A, mechanism of action and role as a potential cancer prevention agent. Planta Medica, 81(11), 927-927.
• Boudreau, P. D., Monroe, E. A., Mehrotra, S., Desfor, S., Korobeynikov, A., Sherman, D. H., ... Gerwick, W. H. (2015). Expanding the described metabolome of the marine cyanobacterium Moorea producens JHB through orthogonal natural products workflows. Plos One, 10(7). doi: 10.1371/journal.pone.0133297
• Bertin, M. J., Schwartz, S. L., Lee, J., Korobeynikov, A., Dorrestein, P. C., Gerwick, L., & Gerwick, W. H. (2015). Spongosine production by a Vibrio harveyi strain sssociated with the sponge Tectitethya crypta. Journal of Natural Products, 78(3), 493-499. doi: 10.1021/np5009762
• Mascuch, S. J., Moree, W. J., Hsu, C. C., Turner, G. G., Cheng, T. L., Blehert, D. S., ... Gerwick, L. (2015). Direct detection of fungal siderophores on bats with white-nose syndrome via fluorescence microscopy-guided ambient ionization mass spectrometry. Plos One, 10(3). doi: 10.1371/journal.pone.0119668

2014

• Micallef, M. L., Sharma, D., Bunn, B. M., Gerwick, L., Viswanathan, R., & Moffitt, M. C. (2014). Comparative analysis of hapalindole, ambiguine and welwitindolinone gene clusters and reconstitution of indole-isonitrile biosynthesis from cyanobacteria. Bmc Microbiology, 14(213). doi: 10.1186/s12866-014-0213-7
• Coates, R. C., Podell, S., Korobeynikov, A., Lapidus, A., Pevzner, P., Sherman, D. H., ... Gerwick, W. H. (2014). Characterization of cyanobacterial hydrocarbon composition and distribution of biosynthetic pathways. PLoS ONE, 9(1), e85140. doi: 10.1371/journal.pone.0085140

2013

• Della Sala, G., Hochmuth, T., Costantino, V., Teta, R., Gerwick, W., Gerwick, L., ... Mangoni, A. (2013). Polyketide genes in the marine sponge Plakortis simplex: a new group of mono-modular type I polyketide synthases from sponge symbionts. Environmental Microbiology Reports, 5(6), 809-818. doi: 10.1111/1758-2229.12081
• Gerwick, L., Boudreau, P., Choi, H., Mascuch, S., Villa, F. A., Balunas, M. J., ... Gerwick, W. H. (2013). Interkingdom signaling by structurally related cyanobacterial and algal secondary metabolites. Phytochemistry Reviews, 12(3), 459-465. doi: 10.1007/s11101-012-9237-5
• Hsu, C. C., ElNaggar, M. S., Peng, Y., Fang, J. S., Sanchez, L. M., Mascuch, S. J., ... Dorrestein, P. C. (2013). Real-time metabolomics on living microorganisms using ambient electrospray ionization flow-probe. Analytical Chemistry, 85(15), 7014-7018. doi: 10.1021/ac401613x
• Sanchez, L. M., Knudsen, G. M., Helbig, C., De Muylder, G., Mascuch, S. M., Mackey, Z. B., ... Linington, R. G. (2013). Examination of the Mode of Action of the Almiramide Family of Natural Products against the Kinetoplastid Parasite Trypanosoma brucei. Journal of Natural Products, 76(4), 630-641. doi: 10.1021/np300834q

2012

• McCarthy, J. G., Eisman, E. B., Kulkarni, S., Gerwick, L., Gerwick, W. H., Wipf, P., ... Smith, J. L. (2012). Structural basis of functional group activation by sulfotransferases in complex metabolic pathways. ACS Chemical Biology, 7(12), 1994-2003. doi: 10.1021/cb300385m
• Balunas, M. J., Grosso, M. F., Villa, F. A., Engene, N., McPhail, K. L., Tidgewell, K., ... Gerwick, W. H. (2012). Coibacins A-D, antileishmanial marine cyanobacterial polyketides with intriguing biosynthetic origins. Organic Letters, 14(15), 3878-3881. doi: 10.1021/ol301607q
• Kim, J. W., Gerwick, L., & Park, C. I. (2012). Molecular identification and expression analysis of two distinct BPI/LBPs (bactericidal permeability-increasing protein/LPS-binding protein) from rock bream, Oplegnathus fasciatus. Fish & Shellfish Immunology, 33(1), 75-84. doi: 10.1016/j.fsi.2012.04.003
• Choi, H., Mascuch, S. J., Villa, F. A., Byrum, T., Teasdale, M. E., Smith, J. E., ... Gerwick, W. H. (2012). Honaucins A-C, potent inhibitors of inflammation and bacterial quorum sensing: synthetic derivatives and structure-activity relationships. Chemistry & Biology, 19(5), 589-598. doi: 10.1016/j.chembiol.2012.03.014
• Jones, A. C., Ottilie, S., Eustaquio, A. S., Edwards, D. J., Gerwick, L., Moore, B. S., & Gerwick, W. H. (2012). Evaluation of Streptomyces coelicolor A3(2) as a heterologous expression host for the cyanobacterial protein kinase C activator lyngbyatoxin A. FEBS Journal, 279(7), 1243-1251. doi: 10.1111/j.1742-4658.2012.08517.x
• Gehret, J. J., Gu, L. C., Geders, T. W., Brown, W. C., Gerwick, L., Gerwick, W. H., ... Smith, J. L. (2012). Structure and activity of DmmA, a marine haloalkane dehalogenase. Protein Science, 21(2), 239-248. doi: 10.1002/pro.2009
• Carland, T. M., Locke, J. B., Nizet, V., & Gerwick, L. (2012). Differential expression and intrachromosomal evolution of the sghC1q genes in zebrafish (Danio rerio). Developmental and Comparative Immunology, 36(1), 31-38. doi: 10.1016/j.dci.2011.05.013

2011

• Engene, N., Choi, H., Esquenazi, E., Byrum, T., Villa, F. A., Cao, Z. Y., ... Gerwick, W. H. (2011). Phylogeny-guided isolation of ethyl tumonoate a from the marine cyanobacterium cf. Oscillatoria margaritifera. Journal of Natural Products, 74(8), 1737-1743. doi: 10.1021/np200236c
• Udwary, D. W., Gontang, E. A., Jones, A. C., Jones, C. S., Schultz, A. W., Winter, J. M., ... Moore, B. S. (2011). Significant natural product biosynthetic potential of actinorhizal symbionts of the genus Frankia, as revealed by comparative genomic and proteomic analyses. Applied and Environmental Microbiology, 77(11), 3617-3625. doi: 10.1128/aem.00038-11
• Jones, A. C., Monroe, E. A., Podell, S., Hess, W. R., Klages, S., Esquenazi, E., ... Gerwick, L. (2011). Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula. Proceedings of the National Academy of Sciences of the United States of America, 108(21), 8815-8820. doi: 10.1073/pnas.1101137108
• Grindberg, R. V., Ishoey, T., Brinza, D., Esquenazi, E., Coates, R. C., Liu, W. T., ... Gerwick, W. H. (2011). Single cell genome amplification accelerates identification of the apratoxin biosynthetic pathway from a complex microbial assemblage. PLoS One, 6(4). doi: 10.1371/journal.pone.0018565
• Malloy, K. L., Villa, F. A., Engene, N., Matainaho, T., Gerwick, L., & Gerwick, W. H. (2011). Malyngamide 2, an oxidized lipopeptide with nitric oxide inhibiting activity from a Papua New Guinea marine cyanobacterium. Journal of Natural Products, 74(1), 95-98. doi: 10.1021/np1005407

2010

• Carland, T. M., & Gerwick, L. (2010). The C1q domain containing proteins: Where do they come from and what do they do?. Developmental and Comparative Immunology, 34(8), 785-790. doi: 10.1016/j.dci.2010.02.014
• Villa, F. A., & Gerwick, L. (2010). Marine natural product drug discovery: Leads for treatment of inflammation, cancer, infections, and neurological disorders. Immunopharmacology and Immunotoxicology, 32(2), 228-237. doi: 10.3109/08923970903296136
• Villa, F. A., Lieske, K., & Gerwick, L. (2010). Selective MyD88-dependent pathway inhibition by the cyanobacterial natural product malyngamide F acetate. European Journal of Pharmacology, 629(1-3), 140-146. doi: 10.1016/j.ejphar.2009.12.002
• Jones, A. C., Monroe, E. A., Eisman, E. B., Gerwick, L., Sherman, D. H., & Gerwick, W. H. (2010). The unique mechanistic transformations involved in the biosynthesis of modular natural products from marine cyanobacteria. Natural Product Reports, 27(7), 1048-1065. doi: 10.1039/c000535e

2009

• Jones, A. C., Gerwick, L., Gonzalez, D., Dorrestein, P. C., & Gerwick, W. H. (2009). Transcriptional analysis of the jamaicamide gene cluster from the marine cyanobacterium Lyngbya majuscula and identification of possible regulatory proteins. BMC Microbiology, 9(247). doi: 10.1186/1471-2180-9-247
• Gu, L. C., Wang, B., Kulkarni, A., Gehret, J. J., Lloyd, K. R., Gerwick, L., ... Sherman, D. H. (2009). Polyketide decarboxylative chain termination preceded by o-sulfonation in curacin a biosynthesis. Journal of the American Chemical Society, 131(44), 16033-+. doi: 10.1021/ja9071578
• Gu, L. C., Wang, B., Kulkarni, A., Geders, T. W., Grindberg, R. V., Gerwick, L., ... Sherman, D. H. (2009). Metamorphic enzyme assembly in polyketide diversification. Nature, 459(7247), 731-735. doi: 10.1038/nature07870

2008

• Simmons, T. L., Engene, N., Urena, L. D., Romero, L. I., Ortega-Barria, E., Gerwick, L., & Gerwick, W. H. (2008). Viridamides A and B, lipodepsipeptides with antiprotozoal activity from the marine cyanobacterium Oscillatoria nigro-viridis. Journal of Natural Products, 71(9), 1544-1550. doi: 10.1021/np800110e
• Gerwick, L., Gerwick, W. H., Coates, R. C., Engene, N., Grindberg, R. V., Jones, A. C., & Sorrels, C. M. (2008). Giant marine cyanobacteria produce exciting potential pharmaceuticals. Microbe, 3(6), 277-284.

2007

• Momoda, T. S., Schwindt, A. R., Feist, G. W., Gerwick, L., Bayne, C. J., & Schreck, C. B. (2007). Gene expression in the liver of rainbow trout, Oncorhynchus mykiss, during the stress response. Comparative Biochemistry and Physiology D-Genomics & Proteomics, 2(4), 303-315. doi: 10.1016/j.cbd.2007.06.002
• Gerwick, L., Corley-Smith, G., & Bayne, C. J. (2007). Gene transcript changes in individual rainbow trout livers following an inflammatory stimulus. Fish & Shellfish Immunology, 22(3), 157-171. doi: 10.1016/j.fsi.2006.04.003

2006

• Bayne, C. J., Gerwick, L., Wheeler, P. A., & Thorgaard, G. H. (2006). Transcriptome profiles of livers and kidneys from three rainbow trout (Oncorhynchus mykiss) clonal lines distinguish stocks from three allopatric populations. Comparative Biochemistry and Physiology D-Genomics & Proteomics, 1(4), 396-403. doi: 10.1016/j.cbd.2006.10.001

2005

• Gerwick, L., Corley-Smith, G. E., Nakao, M., Watson, J., & Bayne, C. J. (2005). Intracranial injections induce local transcription of a gene encoding precerebellin-like protein. Fish Physiology and Biochemistry, 31(4), 363-372. doi: 10.1007/s10695-005-4588-0
• Tilton, S. C., Gerwick, L. G., Hendricks, J. D., Rosato, C. S., Corley-Smith, G., Givan, S. A., ... Williams, D. E. (2005). Use of a rainbow trout oligonucleotide microarray to determine transcriptional patterns in aflatoxin B-1-induced hepatocellular carcinoma compared to adjacent liver. Toxicological Sciences, 88(2), 319-330. doi: 10.1093/toxsci/kfi309

2003

• Fujiki, K., Gerwick, L., Bayne, C. J., Mitchell, L., Gauley, J., Bols, N., & Dixon, B. (2003). Molecular cloning and characterization of rainbow trout (Oncorhynchus mykiss) CCAAT/enhancer binding protein beta. Immunogenetics, 55(4), 253-261. doi: 10.1007/s00251-003-0576-7

2002

• Gerwick, L., Steinhauer, R., Lapatra, S., Sandell, T., Ortuno, J., Hajiseyedjavadi, N., & Bayne, C. J. (2002). The acute phase response of rainbow trout (Oncorhynchus mykiss) plasma proteins to viral, bacterial and fungal inflammatory agents. Fish & Shellfish Immunology, 12(3), 229-242. doi: 10.1006/fsim.2001.0367

2001

• Bayne, C. J., & Gerwick, L. (2001). The acute phase response and innate immunity of fish. Developmental and Comparative Immunology, 25(8-9), 725-743. doi: 10.1016/s0145-305x(01)00033-7
• Bayne, C. J., Gerwick, L., Fujiki, K., Nakao, M., & Yano, T. (2001). Immune-relevant (including acute phase) genes identified in the livers of rainbow trout, Oncorhynchus mykiss, by means of suppression subtractive hybridization. Developmental and Comparative Immunology, 25(3), 205-217. doi: 10.1016/s0145-305x(00)00057-4

2000

• Gerwick, L., Reynolds, W. S., & Bayne, C. J. (2000). A precerebellin-like protein is part of the acute phase response in rainbow trout, Oncorhynchus mykiss. Developmental and Comparative Immunology, 24(6-7), 597-607. doi: 10.1016/s0145-305x(00)00016-1

1999

• Gerwick, L., Demers, N. E., & Bayne, C. J. (1999). Modulation of stress hormones in rainbow trout by means of anesthesia, sensory deprivation and receptor blockade. Comparative Biochemistry and Physiology a-Molecular and Integrative Physiology, 124(3), 329-334. doi: 10.1016/s1095-6433(99)00126-9