Ngo, T.-E., Ecker, A., Ryu, B., Guild, A., Remmel, A., Boudreau, P. D., Alexander, K. L., Naman, C. B., Glukhov, E., Avalon, N. E., Shende, V. V., Thomas, L., Dahesh, S., Nizet, V., Gerwick, L., & Gerwick, W. H. (2024). Structure and Biosynthesis of Hectoramide B, a Linear Depsipeptide from Marine Cyanobacterium Moorena producens JHB Discovered via Coculture with Candida albicans. ACS Chemical Biology, 19(3), 619–628. https://doi.org/10.1021/acschembio.3c00391

Leão, T. F., Wang, M., da Silva, R., Gurevich, A., Bauermeister, A., Gomes, P. W. P., Brejnrod, A., Glukhov, E., Aron, A. T., Louwen, J. J. R., Kim, H. W., Reher, R., Fiore, M. F., van der Hooft, J. J. J., Gerwick, L., Gerwick, W. H., Bandeira, N., & Dorrestein, P. C. (2022). NPOmix: A machine learning classifier to connect mass spectrometry fragmentation data to biosynthetic gene clusters. PNAS Nexus, 1(5), pgac257. https://doi.org/10.1093/pnasnexus/pgac257

Taton, A., Rohrer, S., Diaz, B., Reher, R., Caraballo Rodriguez, A. M., Pierce, M. L., Dorrestein, P. C., Gerwick, L., Gerwick, W. H., & Golden, J. W. (2022). Heterologous Expression in Anabaena of the Columbamide Pathway from the Cyanobacterium Moorena bouillonii and Production of New Analogs. ACS Chemical Biology, 17(7), 1910–1923. https://doi.org/10.1021/acschembio.2c00347

Demirkiran, O., Almaliti, J., Leao, T., Navarro, G., Byrum, T., Valeriote, F. A., Gerwick, L., & Gerwick, W. H. (2021). Portobelamides A and B and Caciqueamide, Cytotoxic Peptidic Natural Products from a Caldora sp. Marine Cyanobacterium. Journal of Natural Products, 84(8), 2081–2093. https://doi.org/10.1021/acs.jnatprod.0c01383

Schorn, M. A., Verhoeven, S., Ridder, L., Huber, F., Acharya, D. D., Aksenov, A. A., Aleti, G., Moghaddam, J. A., Aron, A. T., Aziz, S., Bauermeister, A., Bauman, K. D., Baunach, M., Beemelmanns, C., Beman, J. M., Berlanga-Clavero, M. V., Blacutt, A. A., Bode, H. B., Boullie, A., … van der Hooft, J. J. J. (2021). A community resource for paired genomic and metabolomic data mining. Nature Chemical Biology. https://doi.org/10.1038/s41589-020-00724-z

Christy, M. P., Uekusa, Y., Gerwick, L., & Gerwick, W. H. (2021). Natural products with potential to treat RNA virus pathogens including SARS-CoV-2. Journal of Natural Products, 84(1), 161–182. https://doi.org/10.1021/acs.jnatprod.0c00968

Leao, T., Wang, M. X., Moss, N., da Silva, R., Sanders, J., Nurk, S., Gurevich, A., Humphrey, G., Reher, R., Zhu, Q. Y., Belda-Ferre, P., Glukhov, E., Whitner, S., Alexander, K. L., Rex, R., Pevzner, P., Dorrestein, P. C., Knight, R., Bandeira, N., … Gerwick, L. (2021). A multi-omics characterization of the natural product potential of tropical filamentous marine cyanobacteria. Marine Drugs, 19(1). https://doi.org/10.3390/md19010020

Taton, A., Ecker, A., Diaz, B., Moss, N. A., Anderson, B., Reher, R., Leao, T. F., Simkovsky, R., Dorrestein, P. C., Gerwick, L., Gerwick, W. H., & Golden, J. W. (2020). Heterologous expression of cryptomaldamide in a cyanobacterial host. Acs Synthetic Biology, 9(12), 3364–3376. https://doi.org/10.1021/acssynbio.0c00431

Yang, J. M., Liu, Y. Y., Yang, W. C., Ma, X. X., Nie, Y. Y., Glukhov, E., Gerwick, L., Gerwick, W. H., Lei, X. L., & Zhang, Y. (2020). An anti-inflammatory isoflavone from soybean inoculated with a marine fungusAspergillus terreusC23-3. Bioscience Biotechnology and Biochemistry, 84(8), 1546–1553. https://doi.org/10.1080/09168451.2020.1764838

Li, Y. Y., Yu, H. B., Zhang, Y., Leao, T., Glukhov, E., Pierce, M. L., Zhang, C., Kim, H., Mao, H. H., Fang, F., Cottrell, G. W., Murray, T. F., Gerwick, L., Guan, H. S., & Gerwick, W. H. (2020). Pagoamide A, a cyclic depsipeptide isolated from a cultured marine chlorophyte, Derbesia sp., using MS/MS-based molecular networking. Journal of Natural Products, 83(3), 617–625. https://doi.org/10.1021/acs.jnatprod.9b01019

Cao, L., Gurevich, A., Alexander, K. L., Naman, C. B., Leao, T., Glukhov, E., Luzzatto-Knaan, T., Vargas, F., Quinn, R., Bouslimani, A., Nothias, L. F., Singh, N. K., Sanders, J. G., Benitez, R. A. S., Thompson, L. R., Hamid, M. N., Morton, J. T., Mikheenko, A., Shlemov, A., … Mohimani, H. (2019). MetaMiner: A scalable peptidogenomics approach for discovery of ribosomal peptide natural products with blind modifications from microbial communities. Cell Systems, 9(6), 600-+. https://doi.org/10.1016/j.cels.2019.09.004

Yu, H. B., Glukhov, E., Li, Y. Y., Iwasaki, A., Gerwick, L., Dorrestein, P. C., Jiao, B. H., & Gerwick, W. H. (2019). Cytotoxic microcolin lipopeptides from the marine cyanobacterium Moorea producens. Journal of Natural Products, 82(9), 2608–2619. https://doi.org/10.1021/acs.jnatprod.9b00549

Moss, N. A., Seiler, G., Leao, T. F., Castro-Falcon, G., Gerwick, L., Hughes, C. C., & Gerwick, W. H. (2019). Nature’s combinatorial biosynthesis produces vatiamides A-F. Angewandte Chemie-International Edition, 58(27), 9027–9031. https://doi.org/10.1002/anie.201902571

Moss, N. A., Leao, T., Rankin, M. R., McCullough, T. M., Qu, P. P., Korobeynikov, A., Smith, J. L., Gerwick, L., & Gerwick, W. H. (2018). Ketoreductase domain dysfunction expands chemodiversity: Malyngamide biosynthesis in the cyanobacterium Okeania hirsuta. Acs Chemical Biology, 13(12), 3385–3395. https://doi.org/10.1021/acschembio.8b00910

Skiba, M. A., Sikkema, A. P., Moss, N. A., Lowell, A. N., Su, M., Sturgis, R. M., Gerwick, L., Gerwick, W. H., Sherman, D. H., & Smith, J. L. (2018). Biosynthesis of t-Butyl in apratoxin A: functional analysis and architecture of a PKS loading module. Acs Chemical Biology, 13(6), 1640–1650. https://doi.org/10.1021/acschembio.8b00252

Mascuch, S. J., Boudreau, P. D., Carland, T. M., Pierce, N. T., Olson, J., Hensler, M. E., Choi, H., Campanale, J., Hamdoun, A., Nizet, V., Gerwick, W. H., Gaasterland, T., & Gerwick, L. (2018). Marine natural product honaucin A attenuates inflammation by activating the Nrf2-ARE pathway. Journal of Natural Products, 81(3), 506–514. https://doi.org/10.1021/acs.jnatprod.7b00734

Shao, C. L., Mou, X. F., Cao, F., Spadafora, C., Glukhov, E., Gerwick, L., Wang, C. Y., & Gerwick, W. H. (2018). Bastimolide B, an antimalarial 24-membered marine macrolide possessing a tert-butyl group. Journal of Natural Products, 81(1), 211–215. https://doi.org/10.1021/acs.jnatprod.7b00917

Moss, N. A., Leao, T., Glukhov, E., Gerwick, L., & Gerwick, W. H. (2018). Collection, Culturing, and Genome Analyses of Tropical Marine Filamentous Benthic Cyanobacteria. In B. S. Moore (Ed.), Marine Enzymes and Specialized Metabolism, Pt A (Vol. 604, pp. 3–43). Elsevier Academic Press Inc.

Skiba, M. A., Sikkema, A. P., Moss, N. A., Tran, C. L., Sturgis, R. M., Gerwick, L., Gerwick, W. H., Sherman, D. H., & Smith, J. L. (2017). A mononuclear iron-dependent methyltransferase catalyzes initial steps in assembly of the apratoxin A polyketide starter unit. Acs Chemical Biology, 12(12), 3039–3048. https://doi.org/10.1021/acschembio.7b00746

Luzzatto-Knaan, T., Garg, N., Wang, M. X., Glukhov, E., Peng, Y., Ackermann, G., Amir, A., Duggan, B. M., Ryazanov, S., Gerwick, L., Knight, R., Alexandov, T., Bandeira, N., Gerwick, W. H., & Dorrestein, P. C. (2017). Digitizing mass spectrometry data to explore the chemical diversity and distribution of marine cyanobacteria and algae. Elife, 6. https://doi.org/10.7554/eLife.24214

Kinnel, R. B., Esquenazi, E., Leao, T., Moss, N., Mevers, E., Pereira, A. R., Monroe, E. A., Korobeynikov, A., Murray, T. F., Sherman, D., Gerwick, L., Dorrestein, P. C., & Gerwick, W. H. (2017). A maldiisotopic approach to discover natural products: Cryptomaldamide, a hybrid tripeptide from the marine cyanobacterium Moorea producens. Journal of Natural Products, 80(5), 1514–1521. https://doi.org/10.1021/acs.jnatprod.7b00019

Leao, T., Castelao, G., Korobeynikov, A., Monroe, E. A., Podell, S., Glukhov, E., Allen, E. E., Gerwick, W. H., & Gerwick, L. (2017). Comparative genomics uncovers the prolific and distinctive metabolic potential of the cyanobacterial genus Moorea. Proceedings of the National Academy of Sciences of the United States of America, 114(12), 3198–3203. https://doi.org/10.1073/pnas.1618556114

Maloney, F. P., Gerwick, L., Gerwick, W. H., Sherman, D. H., & Smith, J. L. (2016). Anatomy of the beta-branching enzyme of polyketide biosynthesis and its interaction with an acyl-ACP substrate. Proceedings of the National Academy of Sciences of the United States of America, 113(37), 10316–10321. https://doi.org/10.1073/pnas.1607210113

Wang, M. X., Carver, J. J., Phelan, V. V., Sanchez, L. M., Garg, N., Peng, Y., Nguyen, D. D., Watrous, J., Kapono, C. A., Luzzatto-Knaan, T., Porto, C., Bouslimani, A., Melnik, A. V., Meehan, M. J., Liu, W. T., Criisemann, M., Boudreau, P. D., Esquenazi, E., Sandoval-Calderon, M., … Bandeira, N. (2016). Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking. Nature Biotechnology, 34(8), 828–837. https://doi.org/10.1038/nbt.3597

Cummings, S. L., Barbe, D., Leao, T. F., Korobeynikov, A., Engene, N., Glukhov, E., Gerwick, W. H., & Gerwick, L. (2016). A novel uncultured heterotrophic bacterial associate of the cyanobacterium Moorea producens JHB. Bmc Microbiology, 16. https://doi.org/10.1186/s12866-016-0817-1

Moss, N. A., Bertin, M. J., Kleigrewe, K., Leao, T. F., Gerwick, L., & Gerwick, W. H. (2016). Integrating mass spectrometry and genomics for cyanobacterial metabolite discovery. Journal of Industrial Microbiology & Biotechnology, 43(2–3), 313–324. https://doi.org/10.1007/s10295-015-1705-7

Bertin, M. J., Vulpanovici, A., Monroe, E. A., Korobeynikov, A., Sherman, D. H., Gerwick, L., & Gerwick, W. H. (2016). The phormidolide biosynthetic gene cluster: A trans-at pks pathway encoding a toxic macrocyclic polyketide. Chembiochem, 17(2), 164–173. https://doi.org/10.1002/cbic.201500467

Teta, R., Della Sala, G., Glukhov, E., Gerwick, L., Gerwick, W. H., Mangoni, A., & Costantino, V. (2015). Combined LC-MS/MS and molecular networking approach reveals new cyanotoxins from the 2014 cyanobacterial bloom in Green Lake, Seattle. Environmental Science & Technology, 49(24), 14301–14310. https://doi.org/10.1021/acs.est.5b04415

Shao, C. L., Linington, R. G., Balunas, M. J., Centeno, A., Boudreau, P., Zhang, C., Engene, N., Spadafora, C., Mutka, T. S., Kyle, D. E., Gerwick, L., Wang, C. Y., & Gerwick, W. H. (2015). Bastimolide A, a potent antimalarial polyhydroxy macrolide from the marine cyanobacterium Okeania hirsuta. Journal of Organic Chemistry, 80(16), 7849–7855. https://doi.org/10.1021/acs.joc.5b01264

Gerwick, L., Mascuch, S. J., Navarro, G., Boudreau, P., Carland, T. M., Gaasterland, T., & Gerwick, W. H. (2015). Honaucin A, mechanism of action and role as a potential cancer prevention agent. Planta Medica, 81(11), 927–927.

Navarro, G., Cummings, S., Lee, J., Moss, N., Glukhov, E., Valeriote, F. A., Gerwick, L., & Gerwick, W. H. (2015). Isolation of polycavernoside D from a marine cyanobacterium. Environmental Science & Technology Letters, 2(7), 166–170. https://doi.org/10.1021/acs.estlett.5b00116

Boudreau, P. D., Monroe, E. A., Mehrotra, S., Desfor, S., Korobeynikov, A., Sherman, D. H., Murray, T. F., Gerwick, L., Dorrestein, P. C., & Gerwick, W. H. (2015). Expanding the described metabolome of the marine cyanobacterium Moorea producens JHB through orthogonal natural products workflows. PLOS ONE, 10(7). https://doi.org/10.1371/journal.pone.0133297

Kleigrewe, K., Almaliti, J., Tian, I. Y., Kinnel, R. B., Korobeynikov, A., Monroe, E. A., Duggan, B. M., Di Marzo, V., Sherman, D. H., Dorrestein, P. C., Gerwick, L., & Gerwick, W. H. (2015). Combining mass spectrometric metabolic profiling with genomic analysis: A powerful approach for discovering natural products from cyanobacteria. Journal of Natural Products, 78(7), 1671–1682. https://doi.org/10.1021/acs.jnatprod.5b00301

Bertin, M. J., Schwartz, S. L., Lee, J., Korobeynikov, A., Dorrestein, P. C., Gerwick, L., & Gerwick, W. H. (2015). Spongosine production by a Vibrio harveyi strain sssociated with the sponge Tectitethya crypta. Journal of Natural Products, 78(3), 493–499. https://doi.org/10.1021/np5009762

Mascuch, S. J., Moree, W. J., Hsu, C. C., Turner, G. G., Cheng, T. L., Blehert, D. S., Kilpatrick, A. M., Frick, W. F., Meehan, M. J., Dorrestein, P. C., & Gerwick, L. (2015). Direct detection of fungal siderophores on bats with white-nose syndrome via fluorescence microscopy-guided ambient ionization mass spectrometry. PLOS ONE, 10(3). https://doi.org/10.1371/journal.pone.0119668

Micallef, M. L., Sharma, D., Bunn, B. M., Gerwick, L., Viswanathan, R., & Moffitt, M. C. (2014). Comparative analysis of hapalindole, ambiguine and welwitindolinone gene clusters and reconstitution of indole-isonitrile biosynthesis from cyanobacteria. Bmc Microbiology, 14. https://doi.org/10.1186/s12866-014-0213-7

Coates, R. C., Podell, S., Korobeynikov, A., Lapidus, A., Pevzner, P., Sherman, D. H., Allen, E. E., Gerwick, L., & Gerwick, W. H. (2014). Characterization of cyanobacterial hydrocarbon composition and distribution of biosynthetic pathways. PLOS ONE, 9(1), e85140. https://doi.org/10.1371/journal.pone.0085140

Della Sala, G., Hochmuth, T., Costantino, V., Teta, R., Gerwick, W., Gerwick, L., Piel, J., & Mangoni, A. (2013). Polyketide genes in the marine sponge Plakortis simplex: a new group of mono-modular type I polyketide synthases from sponge symbionts. Environmental Microbiology Reports, 5(6), 809–818. https://doi.org/10.1111/1758-2229.12081

Gerwick, L., Boudreau, P., Choi, H., Mascuch, S., Villa, F. A., Balunas, M. J., Malloy, K. L., Teasdale, M. E., Rowley, D. C., & Gerwick, W. H. (2013). Interkingdom signaling by structurally related cyanobacterial and algal secondary metabolites. Phytochemistry Reviews, 12(3), 459–465. https://doi.org/10.1007/s11101-012-9237-5

Hsu, C. C., ElNaggar, M. S., Peng, Y., Fang, J. S., Sanchez, L. M., Mascuch, S. J., Moller, K. A., Alazzeh, E. K., Pikula, J., Quinn, R. A., Zeng, Y., Wolfe, B. E., Dutton, R. J., Gerwick, L., Zhang, L. X., Liu, X. T., Mansson, M., & Dorrestein, P. C. (2013). Real-time metabolomics on living microorganisms using ambient electrospray ionization flow-probe. Analytical Chemistry, 85(15), 7014–7018. https://doi.org/10.1021/ac401613x

Sanchez, L. M., Knudsen, G. M., Helbig, C., De Muylder, G., Mascuch, S. M., Mackey, Z. B., Gerwick, L., Clayton, C., McKerrow, J. H., & Linington, R. G. (2013). Examination of the Mode of Action of the Almiramide Family of Natural Products against the Kinetoplastid Parasite Trypanosoma brucei. Journal of Natural Products, 76(4), 630–641. https://doi.org/10.1021/np300834q

McCarthy, J. G., Eisman, E. B., Kulkarni, S., Gerwick, L., Gerwick, W. H., Wipf, P., Sherman, D. H., & Smith, J. L. (2012). Structural basis of functional group activation by sulfotransferases in complex metabolic pathways. Acs Chemical Biology, 7(12), 1994–2003. https://doi.org/10.1021/cb300385m

Balunas, M. J., Grosso, M. F., Villa, F. A., Engene, N., McPhail, K. L., Tidgewell, K., Pineda, L. M., Gerwick, L., Spadafora, C., Kyle, D. E., & Gerwick, W. H. (2012). Coibacins A-D, antileishmanial marine cyanobacterial polyketides with intriguing biosynthetic origins. Organic Letters, 14(15), 3878–3881. https://doi.org/10.1021/ol301607q

Kim, J. W., Gerwick, L., & Park, C. I. (2012). Molecular identification and expression analysis of two distinct BPI/LBPs (bactericidal permeability-increasing protein/LPS-binding protein) from rock bream, Oplegnathus fasciatus. Fish & Shellfish Immunology, 33(1), 75–84. https://doi.org/10.1016/j.fsi.2012.04.003

Choi, H., Mascuch, S. J., Villa, F. A., Byrum, T., Teasdale, M. E., Smith, J. E., Preskitt, L. B., Rowley, D. C., Gerwick, L., & Gerwick, W. H. (2012). Honaucins A-C, potent inhibitors of inflammation and bacterial quorum sensing: synthetic derivatives and structure-activity relationships. Chemistry & Biology, 19(5), 589–598. https://doi.org/10.1016/j.chembiol.2012.03.014

Jones, A. C., Ottilie, S., Eustaquio, A. S., Edwards, D. J., Gerwick, L., Moore, B. S., & Gerwick, W. H. (2012). Evaluation of Streptomyces coelicolor A3(2) as a heterologous expression host for the cyanobacterial protein kinase C activator lyngbyatoxin A. FEBS Journal, 279(7), 1243–1251. https://doi.org/10.1111/j.1742-4658.2012.08517.x

Gehret, J. J., Gu, L. C., Geders, T. W., Brown, W. C., Gerwick, L., Gerwick, W. H., Sherman, D. H., & Smith, J. L. (2012). Structure and activity of DmmA, a marine haloalkane dehalogenase. Protein Science, 21(2), 239–248. https://doi.org/10.1002/pro.2009

Carland, T. M., Locke, J. B., Nizet, V., & Gerwick, L. (2012). Differential expression and intrachromosomal evolution of the sghC1q genes in zebrafish (Danio rerio). Developmental and Comparative Immunology, 36(1), 31–38. https://doi.org/10.1016/j.dci.2011.05.013

Engene, N., Choi, H., Esquenazi, E., Byrum, T., Villa, F. A., Cao, Z. Y., Murray, T. F., Dorrestein, P. C., Gerwick, L., & Gerwick, W. H. (2011). Phylogeny-guided isolation of ethyl tumonoate a from the marine cyanobacterium cf. Oscillatoria margaritifera. Journal of Natural Products, 74(8), 1737–1743. https://doi.org/10.1021/np200236c

Udwary, D. W., Gontang, E. A., Jones, A. C., Jones, C. S., Schultz, A. W., Winter, J. M., Yang, J. Y., Beauchemin, N., Capson, T. L., Clark, B. R., Esquenazi, E., Eustaquio, A. S., Freel, K., Gerwick, L., Gerwick, W. H., Gonzalez, D., Liu, W. T., Malloy, K. L., Maloney, K. N., … Moore, B. S. (2011). Significant natural product biosynthetic potential of actinorhizal symbionts of the genus Frankia, as revealed by comparative genomic and proteomic analyses. Applied and Environmental Microbiology, 77(11), 3617–3625. https://doi.org/10.1128/aem.00038-11